Carcinogenic polycyclic aromatic hydrocarbon‐DNA adducts and mechanism of action

By William M. Baird, L. Hooven, B. Mahadevan. Environmental and Molecular Mutagenesis, 2005

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Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. (2007, background): “However, there is a potential for adverse effects, because some procarcinogens require biotransformation by phase I enzymes to become active carcinogens [84].”
Indole glucosinolate breakdown and its biological effects (2008, background): “This negative effect seems to also result from the induction of phase 1 enzymes, due to their potential of oxidizing inert polyaromatic hydrocarbons into DNA-binding products ( Baird et al. 2005, Fig. 8).”