Optimization of laccase production by Botryosphaeria sp. in the presence of veratryl alcohol by the response-surface method

By A. F. Vasconcelos, A. M. Barbosa, R. Dekker, I. Scarminio, M. I. Rezende. 2000

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Modelling of Spirulina platensis growth in fresh water using response surface methodology (2002, methodology): “The response surface method consists of an empirical modelling system that evaluates the relationship between a group of variables that can be controlled experimentally and an observed response (Vasconcelos et al. 2000).”
The influence of medium design on lovastatin production and pellet formation with a high-producing mutant of Aspergillus terreus in submerged cultures (2003, methodology): “Here, we combined response surface methodology (RSM) [13] with experimental designs to identify important ingredients and to evaluate their relative significance in a limited number of experiments.”
Fungal laccases - occurrence and properties. (2006, background): “Laccase activity has been described in both genera, but whereas Bothryosphaeria produces constitutively a dimethoxyphenol-oxidizing enzyme that is probably a true laccase (Vasconcelos et al., 2000), only some strains of Trichoderma exhibit a low level of production of a syringaldazine-oxidizing enzy”