Lactic Acid Permeabilizes Gram-Negative Bacteria by Disrupting the Outer Membrane

By H. Alakomi, E. Skyttä, Maria Saarela, T. Mattila-Sandholm, K. Latva-Kala, I. Helander. Applied and Environmental Microbiology, 2000

1,114 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/3bf0cc3031e6e5768d288f5aeb560b8ae3db13da

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In Microbiology

B. B. Finlay

In Molecular Biology

Citations in the corpus

Perspectives on the use of organic acids and short chain fatty acids as antimicrobials. (2003, background): “Less direct antibacterial activities have also been attributed to organic acids and include interference with nutrient transport, cytoplasmic membrane damage resulting in leakage, disruption of outer membrane permeability, and influencing macromolecular synthesis (Cherrington et al., 1991; Denyer an”
Isolation and screening of lactic acid bacteria from Thai traditional fermented fish (Plasom) and production of Plasom from selected strains (2011, background): “It may also act as a potentiator of the effects of other antimicrobial substances (Alakomi et al., 2000).”
The Vaginal Microenvironment: The Physiologic Role of Lactobacilli (2018, background): “, thereby potentiating the antimicrobial effect of other substances (40).”
Improving the safety of fresh meat (2005, background): “…pHi and the pH membrane gradients, increasing the proportion of saturated fatty acids in the membrane and synthesizing acid-shock proteins (Gould, 1995; Brown et al., 1997; Diez-Gonzalez and Russell, 1997; Chang and Cronan, 1999; Sofos and Busta, 1999; Alakomi et al., 2000; Yuk and Marshall, 2004).”
Genes and Molecules of Lactobacilli Supporting Probiotic Action (2008, background): “Besides exerting its activity through lowering the pH and through its undissociated form, lactic acid is also known to function as a permeabilizer of the gram-negative bacterial outer membrane (2), allowing other compounds to act synergistically with lactic acid.”
Gut microbiota in health and disease. (2010, background): “Members of the Lactobacillus genus produce lactic acid which, in addition to providing an inhibitory environment to the growth of many bacteria, also potentiates the antimicrobial activity of host lysozyme by disrupting the bacterial outer membrane (4).”
The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women (2014, background): “5) through the production of lactic acid [24,27-34].”