Tobacco-smoking-related differential DNA methylation: 27K discovery and replication.

By L. Breitling, Rongxi Yang, B. Korn, B. Burwinkel, H. Brenner. American Journal of Human Genetics, 2011

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450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy (2012, methodology): “A study using the 27K platform observed differences in DNA methylation associated with smoking status in adults at CpG cg03636183 in F2RL3, a gene associated with cardiovascular disease (Breitling et al. 2011).”
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling (2016, background): “HM27 allowed researchers to explore the role of DNA methylation in carcinogenesis and identify cancer biomarkers [9] and for the first time perform largescale ‘epigenome-wide association studies’ (EWAS), which revealed the associations between DNA methylation patterns and tobacco smoking [10], agein”
An epigenetic biomarker of aging for lifespan and healthspan (2018, background): “Cigarette exposure has been shown to have an epigenetic fingerprint[35-37], which has been reflected in previous DNAm risk predictors[38].”
Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation (2013, background): “For the replication panel that was also analyzed with the 450K BeadChip , 479 individuals ( never , former and current smokers ) from the F3 cohort were selected .”