Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors.

By M. Tomizawa, John E. Casida. Annual Review of Entomology, 2003

912 citations recorded by the source corpus.

Subfields: Insect Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3b6004934bf6e5ed259a8e2a5feac67323c2e5f9

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In Insect Science

1. Dave Goulson
2. C. Morrissey
3. P. Mineau
4. D. Gibbons
5. Kathleen A. Durkin
6. A. Biondi
7. F. Bayo
8. N. Simon-Delso

In Molecular Biology

1. Kathleen A. Durkin
2. N. Benowitz
3. Dave Goulson
4. F. Bayo
5. John E. Casida
6. N. Desneux
7. E. Mitchell
8. A. Biondi

Citations in the corpus

• Sublethal and transgenerational effects of short-term and chronic exposures to the neonicotinoid nitenpyram on the cotton aphid Aphis gossypii (2016, background): “It targets nicotinic acetylcholine receptors and has low mammalian toxicity and high toxicity to insect pests (Tomizawa et al. 1996; Tomizawa and Casida 2003; Obana et al. 2003).”
• Comparative toxicity of imidacloprid and its transformation product 6-chloronicotinic acid to non-target aquatic organisms: Microalgae Desmodesmus subspicatus and amphipod Gammarus fossarum (2012, background): “Neonicotinoids are agonist of nAChRs [1] and do not exert a direct inhibition of the AChE activity as for example organophosphates.”
• Insecticides Mode of Action in Relation to Their Toxicity to Non-Target Organisms (2012, background): “Their extreme toxicity to insects contrasts with their low toxicity to all vertebrate taxa, and this selectivity is due to a different kind of nACh-R found in vertebrates [38,39].”
• Metabolism and Disposition Kinetics of Nicotine (2005, background): “1) is a natural ingredient in tobacco leaves where it acts as a botanical insecticide (Soloway, 1976; Tomizawa and Casida, 2003).”
• Management Recommendations for Soybean Aphid (Hemiptera: Aphididae) in the United States (2012, background): “The residual activity of systemic neonicotinoid seed treatments breaks down after 35–42 d after planting (typically V2-V4 growth stage) as the plant biomass increases and then the effectiveness of the toxin decreases (Tomizawa and Casida 2003, Johnson et al. 2008, O’Neal and Johnson 2010).”
• Environmental fate and exposure; neonicotinoids and fipronil (2014, background): “Therefore, these compounds are able to act specifically on insect pests while reducing impacts on some nontarget organisms (Tomizawa and Casida 2003, 2005; Tingle et al. 2003).”
• Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites (2014, background): “…and structure of the subunits between insects and mammalian nAChRs explain in part the high selectivity of neonicotinoids to arthropods and the supposed relatively low toxicity to vertebrates (Nauen et al. 1999; Lansdell and Millar 2000; Matsuda et al. 2001; Tomizawa and Casida 2003, 2005).”
• Neuroactive insecticides: targets, selectivity, resistance, and secondary effects. (2013, background): “Primary Target and Agonist Action ACh is the endogenous agonist and principal excitatory transmitter for rapid neurotransmission in the insect central nervous system and the mammalian central and peripheral nervous systems (90, 130, 131, 133).”
• Behavior-Modifying Strategies in IPM: Theory and Practice (2009, background): “…development of effective new generation insecticides for use in tree fruit such as neonicotinoid insecticides and spinosad (Thompson et al., 2000; Tomizawa and Casida, 2003) may slow the adoption of mating disruption, as broad-spectrum insecticides are phased out, because these new generation…”