Study of Telomere Length Reveals Rapid Aging of Human Marrow Stromal Cells following In Vitro Expansion

By Melissa A. Baxter, R. Wynn, S. Jowitt, J. Wraith, L. Fairbairn, I. Bellantuono. Stem Cells, 2004

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Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. (2008, background): “At the organ/tissue level, an age-related link between oxidative stress and bone mineral density has been demonstrated ( Basu et al., 2001; Liu et al., 2004).”
Aging of mesenchymal stem cells. (2006, background): “A decline in replicative lifespan associated with donor age is found in somatic cells (Rubin, 2002), and this was also shown for MSC by Baxter et al. (2004) and Globerson (1997), but not by Liu et al. (2004).”
Biologics for tendon repair (2014, background): “, [152] observed rapid telomere shortening and earlier entry into growth arrest and senescence; Kasper et al.”
Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process (2008, result): “Our results are in line with similar studies from other groups that demonstrate functional implications on differentiation potential [10,11,34,37].”
Mesenchymal stem cell-macrophage crosstalk and bone healing (2018, background): “overexpression of p53, p21, BAX or MYC genes, among other changes [72-75].”