NF-κB: pivotal mediator or innocent bystander in atherogenesis?

By T. Collins, M. Cybulsky. 2001

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Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “Furthermore, oxLDL can also recruit leukocytes to the arterial wall and activates NF-κB, a major proinflammatory transcription factor that is crucial for the induction of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein (MCP)-1 [67].”
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “Consistent with this observation, both acute (4 h) and chronic (5 d) elevation in the plasma FFA concentration inhibits insulin-stimulated tyrosine phosphorylation of IRS-1, the association of the p85 subunit of PI-3 kinase with IRS-1, and activation of phosphoinositol 3-kinase in human skeletal mus”
Inflammation in atherosclerosis (2002, background): “Constituents of modified lipoprotein particles, among them certain oxidized phospholipids and short-chain aldehydes arising from lipoprotein oxidation, can induce transcriptional activation of the VCAM-1 gene mediated in part by nuclear factor-κB (NF-κB”