Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
By H. Dovey, V. John, J. Anderson, L. Chen, P. de Saint Andrieu, L. Fang, S. Freedman, B. Folmer, E. Goldbach, E. J. Holsztynska and 40 more. Journal of Neurochemistry, 2000
884 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/3b13e076614bf5f3f3392ee77fac20c4f2240fb1
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Citations in the corpus
- Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. (2004, methodology): “…cushion formation We have shown that targeted inactivation of Notch in mice impairs endocardial EMT in vivo and in explant 110 GENES & DEVELOPMENT assays in vitro, the latter phenotype being reproduced in wild-type explants cultured with the -secretase inhibitor DAPT (Dovey et al. 2001).”
- The role of microglia in amyloid clearance from the AD brain (2010, background): “Administration of pharmacological inhibitors of b- or c-secretase in these mice reduces amyloid deposition and ameliorates cognitive dysfunction (Comery et al. 2005; Dovey et al. 2001; Sinha et al. 1999).”
- Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. (2004, background): “gSecretase inhibitors (g-Sec-I) have been identified that effectively reduce the cleavage of APP and therefore may provide a form of therapy for Alzheimer’s disease (Dovey et al., 2001).”
- The surface of articular cartilage contains a progenitor cell population (2004, methodology): “Because of their role in Alzheimer’s disease progression, much interest has focused on the development of γ-secretase inhibitors (Dovey et al., 2001), which not only prevent the accumulation of amyloid plaques but also prevent Notch family signalling (Berezovska et al.”