On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis.
By R. Bartus. Experimental Neurology, 2000
798 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/3b10d21b191780d1a9490d5ae51b014989a363cf
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Citations in the corpus
- Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. (2003, background): “, 2000), the cholinergic system (for reviews, see Bartus et al., 1982; Gallagher and Colombo, 1995; Bartus, 2000), modulation of AMPA receptors with ampakines (Granger et al.”
- Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development (2007, background): “Alzheimer's disease and cognitive impairments A convincing body of data indicate that mAChRs have central roles in facilitating cognitive function”
- Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002, background): “Although damage to multiple neurotransmitter systems have been implicated in the pathogenesis of AD, the role of the cholinergic system is believed to be of particular importance.(1,2) Cholinergic basal forebrain (CBF) neurons are the major source of cholinergic innervation to the cerebral cortex an”
- Alzheimer's Disease: Targeting the Cholinergic System (2016, background): “1016/S0091-3057(96)00431-5 [181] Bartus, R.”
- The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development (2003, background): “As a result, the so-called " cholinergic hypothesis " was developed, which essentially states that a loss of cholinergic function in the central nervous system contributes significantly to the cognitive decline associated with advanced age and AD (reviewed, Bartus, 2000).”