The thioredoxin antioxidant system.

By Jun Lu, A. Holmgren. Free Radical Biology & Medicine, 2014

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Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives (2015, neutral): “Indeed, the Trx system together with the glutathione-glutaredoxin (Grx) system (NADPH, glutathione reductase, GSH, and Grx) controls the cellular redox environment and determines a variety of cellular functions including DNA metabolism and repair, transcription, intracellular signaling, cell-cell co”
Selenium and selenocysteine: roles in cancer, health and development (2014, background): “Its principal function is to control the redox state of thioredoxin, which in turn keeps surface-exposed Cys residues in cytosolic and nuclear proteins in the reduced state [73].”
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript disulfide that is reduced by the flavoprotein TXNRD1, using NADPH as the electron donor.”