Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

By M. Vartiainen, S. Guettler, Banafshé Larijani, R. Treisman. Science, 2007

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From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. (2008, background): “Actin in turn may regulate the serum response factor SRF by controlling the nuclear localization of its cofactor MAL (Vartiainen et al., 2007).”
A tense situation: forcing tumour progression (2009, background): “More convincingly, Rho-family GTPases indirectly regulate histone H4 acetylation by shifting the balance of cellular and nuclear pools of F and G actin, which in turn, modifies the association between serum response factor ( SRF ) and its co-activator MAL (also known as MKL1”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “G-actin monomers control gene transcription through interaction with MRTF/MAL (Miralles et al., 2003; Posern and Treisman, 2006; Vartiainen et al., 2007).”