AMPK: guardian of metabolism and mitochondrial homeostasis
By S. Herzig, R. Shaw. Nature reviews. Molecular cell biology, 2017
3,547 citations recorded by the source corpus.
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP levels via the serine/threonine kinase AMP-activated protein kinase (AMPK) complex. Under conditions of low energy, AMPK phosphorylates specific enzymes and growth control nodes to increase ATP generation and decrease ATP consumption. In the past decade, the discovery of numerous new AMPK substrates has led to a more complete understanding of the minimal number of steps required to reprogramme cellular metabolism from anabolism to catabolism. This energy switch controls cell growth and several other cellular processes, including lipid and glucose metabolism and autophagy. Recent studies have revealed that one ancestral function of AMPK is to promote mitochondrial health, and multiple newly discovered targets of AMPK are involved in various aspects of mitochondrial homeostasis, including mitophagy. This Review discusses how AMPK functions as a central mediator of the cellular response to energetic stress and mitochondrial insults and coordinates multiple features of autophagy and mitochondrial biology.
Subfields: Epidemiology, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/3a6cd3d22743b920363f438f63bec51f5c583e05
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Citations in the corpus
- Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “117‐119 The ratio between adenosine monophosphate (AMP) and ATP increases due to the same insufficient energy supply, activating AMP‐activated protein kinase (AMPK) and thereby enhancing autophagy.(120) On the other hand, mitochondrial dysfunction, accumulated ROS, and subsequent DNA damage can occu”
- Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, neutral): “473,474 AMPK activate peroxisome proliferator-activated receptor coactivator-1 α (PGC-1 α ), the key factor in mitochondrial biogenesis, thus enhancing mitochondrial respiratory and metabolic functions.”
- Autophagy in inflammation, infection, and immunometabolism (2021, background): “AMPK and mTOR work as the yin and the yang of cellular metabolism, and act in opposing ways to control both autophagy (Herzig and Shaw, 2018; Liu and Sabatini, 2020) and immunometabolism, profoundly affecting immune cell function (O’Neill and Hardie, 2013; O’Neill et al.”