Major depressive disorder: new clinical, neurobiological, and treatment perspectives
By David J. Kupfer, E. Frank, Mary L. Phillips. The Lancet, 2011
832 citations recorded by the source corpus.
In this Seminar we discuss developments from the past 5 years in the diagnosis, neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and medical comorbidity have been emphasised as important factors in improving the appropriate assessment and management of depression. Advances in neurobiology have also increased, and we aim to indicate genetic, molecular, and neuroimaging studies that are relevant for assessment and treatment selection of this disorder. Further studies of depression-specific psychotherapies, the continued application of antidepressants, the development of new treatment compounds, and the status of new somatic treatments are also discussed. We address two treatment-related issues: suicide risk with selective serotonin reuptake inhibitors, and the safety of antidepressants in pregnancy. Although clear advances have been made, no fully satisfactory treatments for major depression are available.
Subfields: Biological Psychiatry, Pharmacology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/3a52a2d5f39974c3e120112a622100893e52817c
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In Biological Psychiatry
Citations in the corpus
- Inflammation and clinical response to treatment in depression: A meta-analysis. (2015, positive): “To improve the rate and robustness of clinical response in depression there is a need for novel treatment strategies (Kupfer et al., 2012), including enhancing the personalisation of treatment provision using stratification.”
- Thalamic neuromodulation and its implications for executive networks (2014, background): “Serotonergic afferents to the thalamus have not received much attention, in spite of the critical involvement of serotonin in the control of the sleep–wake cycle and in disorders like depression (Monti, 2011; Kupfer et al., 2012).”
- CBT for depression: a pilot RCT comparing mobile phone vs. computer (2013, background): “Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of depression [5,6].”