Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

By Ugur Sahin, E. Derhovanessian, M. Miller, Björn-Philipp Kloke, P. Simon, M. Löwer, V. Bukur, A. Tadmor, U. Luxemburger, Barbara Schrörs and 40 more. Nature, 2017

2,214 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3a2ac3d97cce82d52f3e943ad3ce64acb7b2a412

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Citations in the corpus

mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “designed neopeptide-encoded mRNAs, while the magnitude of the immune response varied from peptide to peptide, which indicates that the mRNA vaccine can be improved by selecting strongly responsive antigens; however, the underlying mechanism is far from fully clear, and it is difficult to ensure that”
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial (2018, methodology): “Next, we defined expression scores, for each cell, for the following genes and signatures, based on the average E of the gene(s) indicated in parenthesis: (1) CD4 (CD4); (2) CD8 (CD8A and CD8B); (3) regulatory T (Treg) cells (FOXP3 and IL2RA); (4) cytotoxic T cells (PRF1, GZMA, GZMK, NKG7 and CST7);”
Neoantigens: promising targets for cancer therapy (2023, background): “For example, neoantigen-specific mRNA vaccines in 13 evaluable melanoma patients activated several neoepitope-specific CD4 and CD8 T cells, greatly reducing the cumulative incidence of recurrences and leading to persistent progression-free survival.(302,335,336) The mRNA-4650 vaccine, which contains”
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. (2019, positive): “First-in-human application of this concept has been tested in 13 patients with metastatic melanoma by Sahin et al. 204 Patients were immunized against ten neoepitopes per individual by injecting naked mRNA intranodally.”