Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

By A. Cuervo, Leonidas Stefanis, R. Fredenburg, P. Lansbury, D. Sulzer. Science, 2004

1,846 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/3a15c7376051fb0dc037f5f0ec749ca3335c4318

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Ralph A. Nixon
2. A. Cuervo
3. Mark P. Mattson
4. D. Rubinsztein
5. Susmita Kaushik
6. Valina L. Dawson
7. T. Dawson
8. K. Guan

In Epidemiology

1. Ralph A. Nixon
2. A. Cuervo
3. D. Rubinsztein
4. Esther Wong
5. Susmita Kaushik
6. H. Ko
7. Sovan Sarkar
8. Leonidas Stefanis

In Neurology

1. Mark P. Mattson
2. A. Cuervo
3. Ralph A. Nixon
4. H. Ko
5. Valina L. Dawson
6. T. Dawson
7. D. Rubinsztein
8. Sovan Sarkar

Citations in the corpus

• Lithium induces autophagy by inhibiting inositol monophosphatase (2005, background): “Unlike wild-type -synuclein, the clearance of these mutant forms is retarded when autophagy is inhibited (Webb et al., 2003; Cuervo et al., 2004).”
• CARGO RECOGNITION FAILURE IS RESPONSIBLE FOR INEFFICIENT AUTOPHAGY IN HUNTINGTON’S DISEASE (2010, background): “or in models expressing pathogenic forms of α-synuclei”
• Genetics of Parkinson's disease. (2012, background): “Wild-type a-synuclein is selectively translocated into lysosomes for degradation (Cuervo et al. 2004), and inhibitors of the lysosomal enzyme b-glucocerebrosidase, mutations in which represent a wellvalidated risk factor for PD, modulate a-synuclein levels (Manning-Bog et al. 2009).”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “…mutated a-syn (Vogiatzi et al., 2008) CMA degrades wild-type a-syn (Cuervo et al., 2004; Vogiatzi et al., 2008) CMA is inhibited by mutated a-syn (Cuervo et al., 2004) CMA activity is reduced in the brain of PD patient (Alvarez-Erviti et al., 2010) Rapamycin (Dehay et al., 2010; Mendelsohn and…”
• Modulation of neurodegeneration by molecular chaperones (2005, background): “It was recently suggested that mutant α-synuclein might antagonize the receptor that is involved in chaperone-mediated autophagy, thereby enhancing the accumulation of toxic misfolded proteins and resulting in cellular dysfunctio”
• Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth (2011, methodology): “Both lysosome binding and uptake assays were carried out as described previously (Cuervo et al., 2004).”