Materials as stem cell regulators
By William L. Murphy, T. McDevitt, A. Engler. Nature Materials, 2014
866 citations recorded by the source corpus.
The stem cell/material interface is a complex, dynamic microenvironment in which the cell and the material cooperatively dictate one another's fate: the cell by remodelling its surroundings, and the material through its inherent properties (such as adhesivity, stiffness, nanostructure or degradability). Stem cells in contact with materials are able to sense their properties, integrate cues via signal propagation and ultimately translate parallel signalling information into cell fate decisions. However, discovering the mechanisms by which stem cells respond to inherent material characteristics is challenging because of the highly complex, multicomponent signalling milieu present in the stem cell environment. In this Review, we discuss recent evidence that shows that inherent material properties may be engineered to dictate stem cell fate decisions, and overview a subset of the operative signal transduction mechanisms that have begun to emerge. Further developments in stem cell engineering and mechanotransduction are poised to have substantial implications for stem cell biology and regenerative medicine.
Subfields: Biomedical Engineering, Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/39e9ae381a0d50b68a453f04d95877ca6f50114c
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Citations in the corpus
- Stem Cell Organoid Engineering (2016, positive): “These arrangements have been shown to support human embryonic stem cell self-renewal and control human MSC differentiation, based on the various configurations of these surfaces (Murphy et al., 2014).”