T cell receptor antagonist peptides induce positive selection.

By K. Hogquist, S. Jameson, W. Heath, J. Howard, M. Bevan, F. Carbone. 1994

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Citations in the corpus

• Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo (2000, background): “1 1 OT-I mice were bred in our specific pathogen-free facility and have a transgenic V a 2V b 5 TCR specific for the OVA 257–264 epitope in the context of H2-K b (43).”
• Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia (2011, methodology): “Isolation and culture of primary CD8 + T lymphocytes Whole spleens were isolated from OT-1 mice (Jackson Laboratories) expressing ovalbumin (SIINFEKL)-specific T-cell receptors on CD8 + T cell”
• Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation (2000, unknown): “TCR have been described previously (22).”
• Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses (2005, methodology): “Developing T cells (thymocytes) signal and respond functionally to self-pMHCs that are non-agonists for T cells in the periphery [18,19].”
• Type I interferon is selectively required by dendritic cells for immune rejection of tumors (2011, unknown): “OT­I transgenic mice on a Rag1  /  background were obtained through the National Institute of Allergy and Infectious Diseases Exchange Program, National Institutes of Health (C57BL6­ Tg ( OT-I ) - RAG1 tm1Mom 004175; Mombaerts et al., 1992; Hogquist et al., 1994).”
• Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance (2002, background): “OVA is known to be presented on the H-2Kb MHC class I molecule to CD8 T cells, including TCR transgenic OT-I T cells (36).”
• Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. (2007, background): “Third, few if any 2W1S:I-Ab+ T cells were detected in the CD4 + or CD8+ T cells of a 2W1S:I-Ab tetramer-enriched sample of spleen and lymph nodes cells from an OVA 257–264:Kb-specific TCR transgenic OT-I mouse (Hogquist et al., 1994) (Fig.”
• A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity (2000, background): “The OT-1 TCR specifically recognizes SIINFEKL, an octameric peptide from ovalbumin (OVA 257–264 ) presented by the class I MHC molecule, H-2K b (ref”
• Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide (2001, background): “and others that antagonize the reactivity of mature T cells toward their cognate peptid”