Rad6-dependent ubiquitination of histone H2B in yeast.
By Kenneth Robzyk, J. Recht, M. Osley. Science, 2000
707 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/39b94310a68a42a6030b4002f83f4ac756d356dc
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Yi Zhang
- A. Shilatifard
- C. D. Allis
- Paul Tempst
- H. Erdjument‐Bromage
- Jerry L. Workman
- D. Reinberg
- S. Berger
Citations in the corpus
- Mechanism and function of deubiquitinating enzymes. (2004, background): “A new perspective on chromatin-mediated gene silencing has emerged recently with the discovery of histone ubiquitination in yeast, which had previously been thought to be absent [84].”
- Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. (2003, methodology): “cipitates from N-terminally Flag-tagged H2B in wild-type and indicated mutant strains were evaluated by Western blot analysis to determine the relative levels of ubiquitin-modified and unmodified Flag-H2B as described previously (Robzyk et al. 2000).”
- Ubiquitin and proteasomes: Protein regulation by monoubiquitin (2001, background): “, but only during the past year have functions been identified for histone ubiquitylatio”
- Role of histone H2A ubiquitination in Polycomb silencing (2004, background): “Although recent studies have uncovered the enzymes involved in histone H2B ubiquitinatio”
- Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast (2002, background): “Moreover, Rad6 is the major cellular activity that ubiquitinates H2B at Lys 123 in yeas”
- Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. (2004, background): “A well-documented exception sistent with predictions, we detected H3-K27 trimethyla-is the yeast S. cerevisiae (Robzyk et al., 2000).”
- Histone ubiquitination: triggering gene activity. (2008, background): “The ubiquitinated residue in H2B corresponds to Lys-123 in S. cerevisiae, Lys-119 in Schizosaccharomyces pombe, and Lys-143 in Arabidopsis (Robzyk et al., 2000; Sridhar et al., 2007; Tanny et al., 2007).”