Interleukin 15: biology and relevance to human disease.

By T. Fehniger, M. Caligiuri. Blood, 2001

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Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor α-Chain1 (2002, background): “Functions specific to IL-15 include the ability to act as a survival factor for several T cell systems in which IL-2 promotes cell death (11).”
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo (2009, positive): “This is a critical question, as we expect most of the IL-15 in HIS mice to be mouse-derived given the low human myeloid ( 15 ) or absent epithelial/stromal cell chimerism (cells likely to be sources of IL-15) ( 10, 19 ).”
Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells (2002, background): “The costimulatory molecule B7–1/CD80 (23–26) and several cytokines (IL-12 [27–29]; IL-15 [30–33]; and IFN / [34–38]) have been implicated in NK activation, and early during infection, DCs can act as a major source of these stimuli (39, 40).”
Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells1 (2002, background): “The expression patterns of IL-2R and IL-15R are quite distinct and this may contribute to differential functions mediated by these cytokines (1).”