Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication

By Z. Pursell, Isabelle Isoz, Else-Britt Lundström, E. Johansson, Thomas A. Kunkel. Science, 2007

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CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. (2010, background): “Thus, whereas Pol e normally synthesizes the leading strand at the replication forks (Pursell et al. 2007; Kunkel and Burgers 2008; Burgers 2009), we and others have proposed that the C-terminal portion of Pol2 has an essential function as a scaffold for other replication proteins (Masumoto et al.”
DNA repair pathways as targets for cancer therapy (2008, background): “This process is carried out by switching the regular polymerases, e and δ, which are responsible for leading and lagging strand synthesis, respectivel”
Regulation of the Rev1–pol ζ complex during bypass of a DNA interstrand cross‐link (2015, unknown): “As such, they are consistent with the notion that in vertebrates, pol e performs leading strand synthesis whereas pol d performs lagging strand synthesis, as previously demonstrated in S. cerevisiae and S. pombe (Pursell et al , 2007; Nick McElhinny et al , 2008; Miyabe et al , 2011).”
Continued primer synthesis at stalled replication forks contributes to checkpoint activation (2010, background): “A study in yeast suggests that continuous and processive replication on the leading strand is mediated primarily by Pol- (Pursell et al., 2007).”