Alkyl Hydroperoxide Reductase Is the Primary Scavenger of Endogenous Hydrogen Peroxide in Escherichia coli

By Lauren Costa Seaver, J. Imlay. Journal of Bacteriology, 2001

803 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis (2007, background): “Therefore, PRXs are efficient when H 2 O 2 levels are low, whereas catalases are efficient when these levels are high 120 .”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “At low H2O2 concentrations, AhpC serves as the primary scavenger, whereas KatG becomes the primary scavenging enzyme at high concentrations (Hillar et al., 2000; Seaver and Imlay, 2001).”
Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “Finally, OxyR is both a positive and a negative regulator of ROS scavenging in D. radiodurans cells exposed to H2O2 (94).”
The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli. (2012, methodology): “Thus, it is a striking finding that bactericidal gold NPs induce cellular death without oxidative damage-related pathways from results of NADþ cycling, ROS generation, and transcriptomic/proteomic analysis, although they induce a slight decrease of low-level H2O2-scavenging ability for E. coli.”