Effect of silver on burn wound infection control and healing: review of the literature.

By B. Atiyeh, M. Costagliola, S. Hayek, S. Dibo. Burns, 2007

1,270 citations recorded by the source corpus.

Silver compounds have been exploited for their medicinal properties for centuries. At present, silver is reemerging as a viable treatment option for infections encountered in burns, open wounds, and chronic ulcers. The gold standard in topical burn treatment is silver sulfadiazine (Ag-SD), a useful antibacterial agent for burn wound treatment. Recent findings, however, indicate that the compound delays the wound-healing process and that silver may have serious cytotoxic activity on various host cells. The present review aims at examining all available evidence about effects, often contradictory, of silver on wound infection control and on wound healing trying to determine the practical therapeutic balance between antimicrobial activity and cellular toxicity. The ultimate goal remains the choice of a product with a superior profile of infection control over host cell cytotoxicity.

Subfields: Materials Chemistry, Organic Chemistry, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/391b7e73e2c4a7df21599d94aba957ced3166e21

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. C. Blawert
2. M. Rai
3. M. Zheludkevich
4. R. Arrabal
5. A. Gade
6. E. Matykina
7. Ajay Singh
8. S. Deshmukh

In Organic Chemistry

1. Radek Zboril

Citations in the corpus

• Introduction to metallic nanoparticles (2010, background): “Moreover, it has also been shown that ionic silver, in the right quantities, is suitable in treating wounds.[82-84] In fact, silver nanoparticles are now replacing silver sulfadiazine as an effective agent in the treatment of wounds.”
• Biosynthesis of Silver Nanoparticles (2014, background): “AgSD binds to cell components including DNA and cause membrane damage (Atiyeh et al., 2007).”
• Plasma electrolytic oxidation coatings with particle additions – A review (2016, background): “Due to the good antibacterial activity of Ag [117], PEO coatings with unreacted Ag particles demonstrated a well-defined antimicrobial effect.”
• Controlled Release of Biologically Active Silver from Nanosilver Surfaces (2010, neutral): “file for targeted delivery to specific tissue or intracellular targets.(7,10)”
• Antifungal activity of silver nanoparticles against Candida spp. (2009, background): “Antibacterial activity of silver-containing materials may help in reducing infections when treating burns [18] as well as in preventing bacterial colonization of prostheses and catheters [19,20].”
• Silver nanoparticles: the powerful nanoweapon against multidrug‐resistant bacteria (2012, background): “Silver ions have capacity to inhibit the bacterial replication, by binding and denaturing bacterial DNA (Landsdown 2002; Castellano et al. 2007).”
• Assessment of Size-Dependent Antimicrobial and Cytotoxic Properties of Silver Nanoparticles (2014, background): “In 1960s, silver sulfadiazine was first used, as an antimicrobial compound, to cure burn patients [1– 3] and has also been used for a long time to deal with various diseases like cauterization, pleurodesis, and skin wounds [1, 4, 5].”
• Silver nanoparticles as a potential antimicrobial additive for weaned pigs. (2009, background): “Besides, metallic silver is potentially less toxic (Wadhera and Fung, 2005) and it would be deactivated at a slower rate by gastric HCl (Atiyeh et al., 2007) than silver salts.”