Introduction to metallic nanoparticles

By V. Mody, R. Siwale, Ajay Singh, H. Mody. Journal of Pharmacy and Bioallied Sciences, 2010

856 citations recorded by the source corpus.

Metallic nanoparticles have fascinated scientist for over a century and are now heavily utilized in biomedical sciences and engineering. They are a focus of interest because of their huge potential in nanotechnology. Today these materials can be synthesized and modified with various chemical functional groups which allow them to be conjugated with antibodies, ligands, and drugs of interest and thus opening a wide range of potential applications in biotechnology, magnetic separation, and preconcentration of target analytes, targeted drug delivery, and vehicles for gene and drug delivery and more importantly diagnostic imaging. Moreover, various imaging modalities have been developed over the period of time such as MRI, CT, PET, ultrasound, SERS, and optical imaging as an aid to image various disease states. These imaging modalities differ in both techniques and instrumentation and more importantly require a contrast agent with unique physiochemical properties. This led to the invention of various nanoparticulated contrast agent such as magnetic nanoparticles (Fe3O4), gold, and silver nanoparticles for their application in these imaging modalities. In addition, to use various imaging techniques in tandem newer multifunctional nanoshells and nanocages have been developed. Thus in this review article, we aim to provide an introduction to magnetic nanoparticles (Fe3O4), gold nanoparticles, nanoshells and nanocages, and silver nanoparticles followed by their synthesis, physiochemical properties, and citing some recent applications in the diagnostic imaging and therapy of cancer.

Subfields: Biomaterials, Biomedical Engineering, Electronic, Optical and Magnetic Materials

View Paper: https://www.semanticscholar.org/paper/2f4fa820d333cefc2e260e0a68a7054fef10ad81

How researchers see this paper

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In Biomedical Engineering

1. M.E.C.M. Rostelato
2. Carla Daruich de Souza
3. S. N. Upadhyay
4. B. Ribeiro Nogueira

In Electronic, Optical and Magnetic Materials

1. M.E.C.M. Rostelato
2. Carla Daruich de Souza
3. B. Ribeiro Nogueira

Citations in the corpus

• Green synthesis of silver nanoparticles using Azadirachta indica leaf extract and its antimicrobial study (2017, background): “About 5000 years ago, silver was used to store food by Romans, Persians, Egyptians and Greeks (Mody et al. 2010).”
• Review of the methodologies used in the synthesis gold nanoparticles by chemical reduction (2019, positive): “This surface modification enables gold nanoparticles to be used extensively in chemical, biological, engineering, and medical applications [7,27,28].”
• Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists (2022, neutral): “This makes them increasingly important materials for the development of nanodevices that can be used in numerous physical, chemical, biological, biomedical, and pharmaceutical applications [41, 42] (these applications are discussed in detail later in the applications section of the review).”
• Green Synthesis of Silver Nanoparticles: A Review (2016, background): “35 bulk materials of the element due to difference in physiochemical properties and surface to volume ratio [1].”