Identification of (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli

By M. Hintz, A. Reichenberg, B. Altincicek, U. Bahr, R. Gschwind, A. Kollas, E. Beck, J. Wiesner, M. Eberl, H. Jomaa. 2001

334 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/38e9338e431c268d084a1e94200e822c355dc7ff

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In Molecular Biology

Citations in the corpus

Elucidation of the Methylerythritol Phosphate Pathway for Isoprenoid Biosynthesis in Bacteria and Plastids. A Metabolic Milestone Achieved through Genomics1 (2002, background): “…bacteria (many of which are acquiring resistance to currently available antibiotics) and in the malaria parasite Plasmodium falciparum, constitutes an ideal target for the development of novel antimalarial and antibacterial agents (Jomaa et al., 1999; Altincicek et al., 2001c; Hintz et al., 2001).”
Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging (2018, background): “peptidic ligands, cytokines, and signaling via NKG2D and similar receptors [28-35], γδ T cells are implicated as early responders in immune responses and/or as innate-adaptive bridging cells, responding to innate signals to then direct the development of the adaptive immune response via secretion of”
γδ T cell effector functions: a blend of innate programming and acquired plasticity (2010, background): “An interesting example of recognition of both stress-induced molecules and PAMPs is provided by human Vγ9Vδ2 + T cells, which are activated by isoprenoid pathway metabolites known as phosphoantigen”
Quantitative assessment of crosstalk between the two isoprenoid biosynthesis pathways in plants by NMR spectroscopy (2004, positive): “More recently, it was shown that the cyclic diphosphate 5 is converted into (E)-1-hydroxy-2-methyl-but-2-enyl 4- diphosphate (6) (Hecht et al., 2001; Hintz et al., 2001; Wolff et al., 2002; Kollas et al., 2002; Rohdich et al., 2003) which is then transformed into IPP and DMAPP (Rohdich et al.,…”