Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis

By N. Mills, H. Törnqvist, S. Robinson, Manuel C Gonzalez, Kareen Darnley, W. Macnee, N. Boon, Ken Donaldson, A. Blomberg, T. Sandstrom and 1 more. Circulation, 2005

662 citations recorded by the source corpus.

Subfields: Cancer Research, Health, Toxicology and Mutagenesis, Immunology

View Paper: https://www.semanticscholar.org/paper/38d6a01351de6264238f6ca711fcbce4dca62f58

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In Cancer Research

W. Macnee

In Health, Toxicology and Mutagenesis

Citations in the corpus

Deposition and biokinetics of inhaled nanoparticles (2010, background): “However, there is indirect evidence of nanoparticle translocation in humans from recent inhalation studies in healthy subjects with diluted Diesel exhaust, which was found to impair the regulation of the vascular tone and fibrinolysis [84].”
Drug delivery and nanoparticles: Applications and hazards (2008, background): “…that combustion and model NPs can gain access to the blood following inhalation or instillation and can enhance experimental thrombosis but it is not clear whether this was an effect of pulmonary inﬂ ammation or particles translocated to the blood (Nemmar et al 2002, 2003; Mills et al 2005).”
Adverse cardiovascular effects of air pollution (2009, background): “When exposed to dilute diesel exhaust, healthy volunteers demonstrated an early and persistent (up to 24 h) impairment of vascular function”
Air Pollution and Cardiovascular Disease: JACC State-of-the-Art Review. (2018, background): “Studies of ultrafine particles, including inhalation of elemental carbon as well as diluted diesel exhaust, have shown that they induce rapid endothelial dysfunction in the microcirculation (111,112).”
Management and Shocks to Worker Productivity (2019, positive): “…matter for short periods in concentrations currently found in polluted urban environments in the laboratory find evidence of adverse cardiovascular effects (Mills et al., 2005), as well as acute vasoconstriction, which may also increase the probability of cardiac events (Brook et al., 2002).”