Mixed brain pathologies account for most dementia cases in community-dwelling older persons

By Julie A. Schneider, Zoe Arvanitakis, W. Bang, David A. Bennett. Neurology, 2007

1,797 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/38419b958c9941fbf606c9a9f875827a3518410b

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Citations in the corpus

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease (2009, neutral): “Logical candidates include cerebro-vascular disease, hippocampal sclerosis or Lewy body disease (Bennett et al ., 2005; Jicha et al ., 2006; Schneider et al ., 2007).”
Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “…can account for 40%–70% of the variance in cognition seen in elderly subjects, with additional pathologies such as cerebrovascular disease (Dolan et al. 2010b) and Lewy body pathology (Schneider et al. 2007) working together with AD pathology to account for an additional 20%–30% of dementia cases.”
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology (2014, background): “The burden of vascular and AD-type pathologies are leading and independent causes of dementia in the elderly [4,9-15], suggesting additive or synergistic effects of both types of lesions on cognitive impairment [2,3,5,9,16-29].”
Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade (2010, neutral): “1 , 2 The clinical disease stages of AD have been divided into three phases.”
The pathobiology of vascular dementia (2013, neutral): “…the role of cerebrovascular disease, not only as a primary cause of cognitive impairment, but also as an adjuvant to the expression of dementia caused by other factors, including AD and other neurodegenerative pathologies (Gorelick et al., 2011; Schneider et al., 2007a; Toledo et al., 2013).”
Neuropathological alterations in Alzheimer disease. (2011, background): “Both CERAD and NIA-RI criteria also incorporated the assessment of other pathologies, particularly vascular and Lewy body diseases, already recognizing the high prevalence of mixed pathologies underlying dementia in elderly people, a circumstance well documented by more recent longitudinal community”
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019 (2022, neutral): “41,61 Our study also focused on the estimation of dementia prevalence, as the estimation of the numbers of individuals with dementia is of direct relevance for public health planning efforts.”
The Impact of Age on Cognition (2015, background): “However, mixed dementia or dementia caused by more than one pathology was very common.(27) These same pathologic changes are very common in older adults without dementia.”
2016 Alzheimer's disease facts and figures (2016, neutral): “Vascular dementia with DLB is much less common [5,6].”