The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

By H. Caron, B. V. Schaik, M. V. D. Mee, F. Baas, G. Riggins, P. Sluis, M. Hermus, R. V. Asperen, K. Boon, P. Voute and 3 more. Science, 2001

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Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data (2013, background): “The presence of TADs could provide a chromatin structural explanation for the long-standing observation that groups of neighbouring genes are often correlated in expression across cell types 62,63 .”
The evolutionary dynamics of eukaryotic gene order (2004, background): “Other reports note that highly expressed genes, defined by SERIAL ANALYSIS OF GENE EXPRESSION (SAGE) tags, tend to cluster in large domains (regions of increased gene expression; RIDGEs”
An abundance of bidirectional promoters in the human genome. (2003, background): “…sequences, the transcript levels of the two genes in a bidirectional gene pair may be coordinately regulated (Lee and Song 2000; Ikeda et al. 2002) Drosophila and human genomes showed that genes in the same region of the genome are often coexpressed (Caron et al. 2001; Spellman and Rubin 2002).”
Quantitative Proteomics of the Cancer Cell Line Encyclopedia (2020, neutral): “Correlated expression patterns in gene expression data are organized in large part around chromosomal location, driven by mechanisms such as transcription factor activity and chromosomal topology as set up by cellular and tissue identity (Caron et al., 2001; Dixon et al., 2016; Furlong and Levine, 2”