Disease Modeling in Stem Cell-Derived 3D Organoid Systems.

By Devanjali Dutta, Inha Heo, Hans Clevers. Trends in Molecular Medicine, 2017

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Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “Organoid cultures have been described for a variety of organs, including various normal tissue and disease models of the digestive tract, prostate, lung, kidney and the brain (Clevers, 2016; Fatehullah et al., 2016; Dutta et al., 2017).”
Genetics and biology of prostate cancer (2018, background): “1-expressing cells) (Chua et al. 2014); these models can recapitulate in vivo the structural, functional, and genetic features of the prostate gland and the original disease (Dutta et al. 2017).”