The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells.

By S. Boyle, S. Gilchrist, J. Bridger, Nicola L. Mahy, Juliet A. Ellis, Wendy A. Bickmore. Human Molecular Genetics, 2001

684 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/380dfd9859026b9e02d54be9e0d9e076bb77fd02

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Citations in the corpus

Structure and Dynamics of Interphase Chromosomes (2008, background): “The localization of territories inside the nucleus exhibits regular patterns: gene-rich chromosomes in human lymphocytes preferably locate in the nuclear interior while gene-poor chromosomes are typically found closer to the periphery [12,13]; in contrast, in human fibroblasts positioning of territo”
Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences (2004, background): “Perhaps the intranuclear position of chromosomes may have an influence, since this has been proposed to be relatively fixed for cells of specific types but may differ among cell types (Boyle et al. 2001; Chubb and Bickmore 2003).”
Chromosome territories. (2010, background): “These observations of a gene density correlated radial arrangement in the nucleus were completed and confirmed by analyses comprising all human chromosomes (Boyle et al. 2001).”
Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes (2005, neutral): “[28] and our group [23,24,25,26] provided support for”
Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. (2014, background): “In the body, tissue stiffness ranges several orders of magnitude, from adipose tissue (Young’s Modulus E ~ several kPa) [106] to bone (E ~ GPa) [99].”
Beyond the sequence: cellular organization of genome function. (2007, neutral): “In addition, human lymphocytes show a strong correlation between the radial position of human chromosomes and their gene density, with gene-poor chromosomes positioned toward the nuclear periphery and gene-rich chromosomes located in the nuclear interior (Boyle et al., 2001).”
Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells (2008, methodology): “Even though this is a 2D analysis it can be used to infer 3D organisation [1,2].”
Heterogeneous substitution systems revisited (2016, neutral): “The Sub-6 GHz bandwidth is partitioned into S orthogonal subchannels, indexed by the set S = { 1 , . . . , s , . . . , S } .”