Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway
By M. Marinissen, M. Chiariello, J. Gutkind. 2001
149 citations recorded by the source corpus.
Small GTP-binding proteins of the Rho-family, Rho, Rac, and Cdc42, have been traditionally linked to the regulation of the cellular actin-based cytoskeleton. Rac and Cdc42 can also control the activity of JNK, thus acting in a molecular pathway transmitting extracellular signals to the nucleus. Interestingly, Rho can also regulate gene expression, albeit by a not fully understood mechanism. Here, we found that activated RhoA can stimulate c-jun expression and the activity of the c-jun promoter. As the complexity of the signaling pathways controlling the expression of c-jun has begun to be unraveled, this finding provided a unique opportunity to elucidate the biochemical routes whereby RhoA regulates nuclear events. We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 (p38γ), a recently identified member of the p38 family of MAPKs. Furthermore, we present evidence that RhoA, PKN, MKK3/MKK6, and ERK6 (p38γ) are components of a novel signal transduction pathway involved in the regulation of gene expression and cellular transformation.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/37d46d41bc8759bf95075aec1194a7d9e7e3da43
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Citations in the corpus
- Differential regulation and properties of MAPKs (2007, background): “In NIH-3T3 cells, overexpression of Rho activates p38g specifically in a MEK3-dependent manner (Marinissen et al., 2001).”
- p38 MAP-kinases pathway regulation, function and role in human diseases. (2007, background): “Contributing to p38 activation upstream of MKKK are the low molecular weight GTP-binding proteins from the Rho subfamily such as Rac1, Cd242, Rho and Rit [48–50] and heterotrimeric Gprotein coupled receptors [51].”