RHO–GTPases and cancer

By Erik Sahai, C. Marshall. Nature Reviews. Cancer, 2002

1,555 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/37bd7dca1af806f144b80dd10aca4e00e7e14b1b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Fa-Xing Yu
2. Mahmut Yilmaz
3. Gerhard Christofori
4. K. Guan
5. P. Chiarugi
6. M. Parri
7. A. Hall
8. Walter Kolch

In Molecular Biology

1. Mahmut Yilmaz
2. Fa-Xing Yu
3. Gerhard Christofori
4. P. Chiarugi
5. M. Parri
6. A. Hall
7. J. Colicelli
8. Walter Kolch

In Oncology

1. K. Guan
2. Walter Kolch
3. P. Chiarugi
4. Gerhard Christofori
5. J. Colicelli
6. M. Parri
7. Fa-Xing Yu
8. R. Weinberg

Citations in the corpus

• A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis (2009, neutral): “Guided by this gene ontology analysis, we cloned the 30 UTRs of 16 putative miR-31 targets from these overrepresented categories, including several implicated in tumor invasion (Sahai and Marshall, 2002; McClatchey, 2003), into a luciferase construct.”
• EMT, the cytoskeleton, and cancer cell invasion (2009, background): “In general, RhoGTPases affect almost all cell biological processes in a cell’s life [133–135].”
• MAP kinase signalling pathways in cancer (2007, background): “One important mechanism whereby ERK signalling may promote a more malignant phenotype is by disrupting Rho signalling pathways (Sahai and Marshall, 2002).”
• GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo (2007, background): “dysfunctional.(3,4) This crucial role has led to a comprehensive study on their mechanism of regulation, to the identification of additional elements of their signal transduction pathways, and to the characterization of their roles in vivo.”
• Human RAS Superfamily Proteins and Related GTPases (2004, background): “Mounting evidence supports the involvement of RHO proteins in cancer (189).”
• Rac and Rho GTPases in cancer cell motility control (2010, background): “Beside environmental regulation, MAT can also be induced by epigenetic expression of regulating factors.”
• Anoikis molecular pathways and its role in cancer progression. (2013, background): “In addition, this leads to the PI3K-dependent activation of Rac-1 and Cdc42 at the leading edge of the cell, which coordinate actin polymerization [187].”
• Mutant p53 as a guardian of the cancer cell (2018, neutral): “RhoA is frequently overexpressed or hyper-activated in tumors [21].”