Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.
By M. Warny, J. Pépin, Aiqi Fang, G. Killgore, Angela D. Thompson, J. Brazier, E. Frost, L. McDonald. The Lancet, 2005
1,475 citations recorded by the source corpus.
Subfields: Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/379e991431a679e142328cbb662fc1b7d58bff7d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
- Emily R. M. Sydnor
- L. Chiarello
- J. Siegel
- Trish Perl
- M. Jackson
- J. Bartlett
- E. Rhinehart
- J. H. Morse
In Molecular Biology
Citations in the corpus
- 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings (2007, background): “Furthermore, 4 MRSA reports described continuing success in sustaining low endemic MDRO rates for over 5 years.(68,166,172,173) d A MDR-GNB was eradicated from 13 special care units(8,9,38,174-180) and 2 hospitals.”
- Treatment with monoclonal antibodies against Clostridium difficile toxins. (2010, neutral): “Inpatient 7/50 ( 14 ) 13/52 (25) 11 (−5 to 27) 0.21”
- Emergence of Clostridium difficile-associated disease in North America and Europe. (2006, background): “A recent report indicates that toxinotype III isolates produce TcdA and TcdB in considerably greater quantities in vitro than do toxinotype 0 isolates [56].”
- Hospital Epidemiology and Infection Control in Acute-Care Settings (2011, background): “difficile (338), is associated with a deletion in the gene responsible for the downregulation of toxin production, and is highly resistant to fluoroquinolones (15, 86, 87).”
- Toxin B is essential for virulence of Clostridium difficile (2009, methodology): “Results were recorded as negative (2), weak cytotoxicity (1; less than 10% cell rounding), or high cytotoxicity (111;”
- A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2013 Recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)a (2013, background): “The severity of disease is believed to be due to toxin hyperproduction [113].”
- Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. (2008, background): “For amplification of tcdC, a forward primer that was designed inhouse was used: 5 TTTTCATATGTTTTCTAAAAAAAATGA- GGG 3 (TcdC1s).”