Microfluidic bioprinting of heterogeneous 3D tissue constructs using low viscosity bioink
By C. Colosi, S. Shin, V. Manoharan, Solange Massa, M. Costantini, A. Barbetta, Mehmet Remzi Dokmeci, M. Dentini, Ali Khademhosseini. Advances in Materials, 2015
751 citations recorded by the source corpus.
A novel bioink and a dispensing technique for 3D tissue-engineering applications are presented. The technique incorporates a coaxial extrusion needle using a low-viscosity cell-laden bioink to produce highly defined 3D biostructures. The extrusion system is then coupled to a microfluidic device to control the bioink arrangement deposition, demonstrating the versatility of the bioprinting technique. This low-viscosity cell-responsive bioink promotes cell migration and alignment within each fiber organizing the encapsulated cells.
Subfields: Automotive Engineering, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/378f705b6f1c6aad63e93e19bfa5399930a3da1d
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Citations in the corpus
- Current Status of Bioinks for Micro-Extrusion-Based 3D Bioprinting (2016, methodology): “A study has observed increase in the elastic modulus from 20 to 50 kPa by increasing the UV exposure from 15 s to 60 s [34].”
- Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs (2019, background): “Resulting multicomponent bioinks should have chemical and physical properties that can allow their printability [25].”
- Advances in engineering hydrogels (2017, background): “The emergence of microfluidic printheads capable of codelivering dual material types further enhanced the speed of multimaterial printing via improved switching between the different materials (118, 119, 130, 131).”
- Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip (2016, positive): “Based on the microfluidic technology that we developed in our previous work [37], we demonstrate d hat endothelial cells, directly encapsulated within the bioprinted microfibrous lat tices, gradually migrated towards the peripheries of the microfibers to form a layer of c nfluent endothelium.”