Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.
By L. Vassilev, C. Tovar, Shaoqing Chen, D. Knezevic, Xiaolan Zhao, Hongmao Sun, D. Heimbrook, Li Chen. Proceedings of the National Academy of Sciences of the United States of America, 2006
812 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/377a01193fe78858babb8c62f473407767d2d6d4
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Citations in the corpus
- Cell cycle kinases as therapeutic targets for cancer (2009, background): “2 and Supplementary information S2 (table)) has been reported to be a highly selective inhibitor of CDK1–cyclin B in vitro”
- Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury (2010, neutral): “When we administered R03306, a cyclin-dependent kinase-1 inhibitor known to induce a reversible G2/M transition defec”
- Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance (2010, methodology): “12 Cdc2 activity in mitotic cells also induced mitotic slippage resulting in severe cytokinesis defects (17-19).”