The Role of Non-coding RNAs in Oncology

By Frank J. Slack, Arul M. Chinnaiyan. Cell, 2019

1,345 citations recorded by the source corpus.

For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular activity. An explosion of studies into ncRNA biology has since shown that they represent a diverse and prevalent group of RNAs including both oncogenic molecules and those that work in a tumor suppressive manner. As a result, hundreds of cancer-focused clinical trials involving ncRNAs as novel biomarkers or therapies have begun, and these are likely just the beginning.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c674a6bbeb622729c86b696d7eec43262897223

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. George A. Calin
2. M. Ferracin
3. Kinga Nemeth
4. R. Bayraktar
5. Carlo Maria Croce
6. Joshua T. Mendell
7. Marilena V. Iorio

In Molecular Biology

1. George A. Calin
2. M. Ferracin
3. Kinga Nemeth
4. R. Bayraktar
5. K. Rock
6. Carlo Maria Croce
7. Joshua T. Mendell

Citations in the corpus

• Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “…recent reviews have extensively discussed a range of approaches to modulate the therapeutic potential of ncRNAs, including the use of small interfering RNAs (siRNAs), ASOs, shRNAs, anti-miRNAs, miRNA mimics, miRNA sponges, therapeutic circRNAs and CRISPR–Cas9-based gene editing 53,105,275–278 .”
• Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation (2021, background): “MiRNAs can be blocked in cells by treatment with complementary anti-sense RNAs (antimirRs/antagomiRs) and overexpression of miRNAs can be achieved using miRNA duplexes (miRNA mimetics) (199, 266).”