Layer V cortical neurons require microglial support for survival during postnatal development

By Masaki Ueno, Y. Fujita, Tatsuhide Tanaka, Yuka Nakamura, J. Kikuta, M. Ishii, T. Yamashita. Nature Neuroscience, 2013

718 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes (2018, background): “Another group showed that thesemicrogliawere the predominant source of Igf1 in the early postnatal brain, and Igf1 conditional knockout in microglia affected the health of developing cortical neurons at the same age (Ueno et al., 2013).”
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “101 Microglia can also prevent neuronal hyper-excitability as genetically inhibition of Gi in microglia increases hypersynchrony upon physiologically evoked neuronal activity.”
Origin and Functions of Tissue Macrophages (2014, background): “With respect to neuronal survival, microglia are essential for cortical layer V formation, where they release multiple growth factors, including IGF-1 (Ueno et al., 2013).”
Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing (2018, positive): “classical immune surveillance and scavenging functions, microglia have recently been found to actively participate in neural development by modulating neurogenesis and pruning synapses (Cunningham et al., 2013; Li and Barres, 2017; Paolicelli et al., 2011; Schafer et al., 2012; Ueno et al., 2013).”