The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
By Sebastian M. B. Nijman, Tony T. Huang, A. Dirac, T. Brummelkamp, R. Kerkhoven, A. D’Andrea, René Bernards. Molecules and Cells, 2005
625 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/36bd91ade4fd61e637a6fd0ed239491b6979d479
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In Genetics
In Molecular Biology
- D. Komander
- Stephen P. Jackson
- René Bernards
- Sebastian M. B. Nijman
- A. Dirac
- T. Brummelkamp
- Ivan Dikic
- M. Rapé
Citations in the corpus
- Targeting the ubiquitin system in cancer therapy (2009, background): “USP1 modulates DNA-repair checkpoints by preventing the monoubiquitylation of the Fanconi anaemia complementation group D2 protein (FANCD2) and of proliferating cell nuclear antigen (PCNA”
- The ubiquitin code. (2012, background): “Similar reactions are observed in budding yeast, where proteasomalprocessingofthetranscriptionfac-tor SPT23 is a prerequisite for its release from membrane-bound transcription factor SREBP requires ubiquitin-dependent cleavage (176 Proteasomal processing might involve atypical by U n i e r s y o f C”
- Ubiquitylation and cell signaling (2005, background): “Deubiquitylation of FANCD2 may play a critical role for the recycling of FANCD2 when cells recommence the cell cycle after DNA damage (Nijman et al, 2005).”
- Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. (2007, background): “USP1 is the deubiquitinating enzyme for FANCD2 (Nijman et al., 2005).”
- Regulation and Cellular Roles of Ubiquitin-specific Deubiquitinating Enzymes (2009, background): “Usp1 is proposed to deubiquitinate FANCD2 when cells exit S phase or recommence cycling after DNA damage and may play a critical role in the FA pathway by recycling FANCD2 (49, 178).”
- A genomic and functional inventory of deubiquitinating enzymes. (2005, background): “Moreover, some DUBs have been reported to be transcriptionally regulated (Figure 4B, left panel), sometimes in a cell-cycle-regulated manner (for example, USP1) or as part of a negative feedback loop (such as CYLD; Jono et al., 2004; Nijman et al., 2005).”
- Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “2010), while USP1 counteracts FA protein ubiquitylation (Nijman et al. 2005).”