Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.

By M. E. Guicciardi, J. Deussing, H. Miyoshi, S. Bronk, P. Svingen, C. Peters, S. Kaufmann, G. Gores. Journal of Clinical Investigation, 2000

749 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/369b98713dba28090167d2c5a6827ee2f0a8e543

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. M. Jäättelä
2. Marcel Leist
3. G. Gores
4. S. Aits
5. Guido Kroemer

In Molecular Biology

1. M. Jäättelä
2. Marcel Leist
3. Marcus E. Peter
4. G. Gores
5. Guido Kroemer

Citations in the corpus

• The lysosome: from waste bag to potential therapeutic target. (2013, background): “In addition, proteases, including caspases, calpains and cathepsins, promote the release of lysosomal constituents (Yamashima et al., 1996; Guicciardi et al., 2000; Werneburg et al., 2002; Eriksson et al., 2013).”
• Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor (2001, background): “, 1999), which have recently been reported to contribute to hepatocyte apoptosis (Roberts et al., 1997; Guicciardi et al., 2000).”
• NF‐κB protects from the lysosomal pathway of cell death (2003, background): “Cathepsin B is released into the cytoplasm where it activates caspase-dependent and caspase-independent pathways of cell death (Guicciardi et al., 2000; Ferri and Kroemer, 2001; Foghsgaard et al., 2001).”
• Lysosomes in cell death (2004, background): “…permeabilization appears to be an early event in the apoptotic cascade, preceding other hallmarks of apoptosis like destabilization of mitochondria and caspase activation (Roberg et al., 1999; Guicciardi et al., 2000; Li et al., 2000; Bidere et al., 2003; Boya et al., 2003a, b; Liu et al., 2003).”
• Necrosis: a specific form of programmed cell death? (2003, background): “For instance, TNF-induced cell death of hepatocytes and tumor cells apparently requires lysosomal cysteine protease cathepsine B [143,144].”
• Lysosomal cell death at a glance (2013, background): “, 2011) TNF plus Ad5IkB Mus musculus Liver Hepatitis Ctsb (Guicciardi et al., 2000; Guicciardi et al., 2001) norpA Drosophila melanogaster Eye Retinal degeneration Cp1 mutant, ectopic Cys, ectopic Spn4 (Kinser and Dolph, 2012)”