Specificity and mechanism of action of some commonly used protein kinase inhibitors

By S. Davies, Helen Reddy, M. Caivano, P. Cohen. 2000

1,611 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/368fbf61f8929ed5a44c108d74528f923d1e444c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Zachary A. Knight
2. J. Bain
3. L. Diaz
4. Kevan M. Shokat
5. Yardena Samuels
6. P. Cohen
7. M. Elliott
8. Kenneth W. Kinzler

Citations in the corpus

• Functional diversity of protein phosphatase-1, a cellular economizer and reset button. (2004, background): “(98), an order of magnitude that is in agreement with”
• The specificities of protein kinase inhibitors: an update. (2003, methodology): “Other protein kinases were assayed as described previously in [ 6 ].”
• Features of selective kinase inhibitors. (2005, background): “Two valuable studies have profiled many of the most commonly used kinase inhibitors against 28 protein kinases in this way [62, 63].”
• Mutant PIK3CA promotes cell growth and invasion of human cancer cells. (2005, background): “These results suggest that LY294002, despite its limited specificity for PI3KCA (Davies et al., 2000; Fruman et al., 1998), preferentially inhibits mutant PIK3CA signaling.”