Oxygen sensing, homeostasis, and disease.

By G. Semenza. New England Journal of Medicine, 2011

969 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrine and Autonomic Systems, Genetics

View Paper: https://www.semanticscholar.org/paper/3624e72925f1cbb1f0d20003ab900e2604c2d53a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. Ralph J. Deberardinis
3. Richard J. Johnson
4. Russell G. Jones
5. V. Nizet
6. Cormac T. Taylor
7. B. Faubert
8. S. Kierans

In Endocrine and Autonomic Systems

1. Cormac T. Taylor
2. S. Kierans
3. G. Semenza

In Genetics

1. Cormac T. Taylor
2. G. Semenza
3. Richard J. Johnson
4. Russell G. Jones
5. V. Nizet
6. Ralph J. Deberardinis
7. S. Kierans
8. S. Colgan

Citations in the corpus

• Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology (2020, background): “Binding of the HIF heterodimer to hypoxia responsive elements (HRE) within the promoter/enhancer regions of target genes initiates the transcription of those genes which promote adaptation to hypoxia (Wang et al. 1995; Semenza, 2011).”
• Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions (2023, background): “Oxygen in the TME can anchor broken ends of DNA and form stable organic peroxide groups that inhibit further DNA repair.(434) However, local hypoxia in the TME markedly reduces the therapeutic efficacy of radiation therapy.”
• AMPK is a negative regulator of the Warburg Effect and suppresses tumor growth in vivo (2012, background): “Several of the enzymes elevated in AMPKa-deficient cells are known targets of the transcription factor HIF-1a, one of the central regulators of glycolysis induced by hypoxia (Keith et al., 2012; Semenza, 2011).”
• Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “HIF-1 plays an important role in normal physiology (Semenza, 2011).”
• Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function (2015, positive): “HIF is the major cellular mechanism coordinating the transcriptional response to lowO2 environments (Semenza, 2011).”
• HIF Transcription Factors, Inflammation, and Immunity (2014, background): “Hypoxia-inducible factor (HIF) transcription factors are master regulators of the cellular response to hypoxia and coordinate a transcriptional program that ensures optimal functional, metabolic, and vascular adaptation to O 2 shortages (Semenza, 2011).”
• PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation (2014, background): “2014 Vol. 211 No. 5 781-790 www.jem.org/cgi/doi/10.1084/jem.20131916 781 Brief Definit ive Report Hypoxia is a common feature of solid tumors (Semenza, 2011).”
• Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy (2012, background): “Both the delivery and consumption of O2 are precisely regulated through the activity of hypoxia-inducible factors (HIFs) [1].”