A cortical–hippocampal–cortical loop of information processing during memory consolidation

By Gideon Rothschild, Elad Eban, Loren M. Frank. 2016

352 citations recorded by the source corpus.

Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a rapid cortical–hippocampal–cortical loop of information flow around the times of SWRs. We recorded neural activity in auditory cortex (AC) and hippocampus of rats as they learned a sound-guided task and during sleep. We found that patterned activation in AC precedes and predicts the subsequent content of hippocampal activity during SWRs, while hippocampal patterns during SWRs predict subsequent AC activity. Delivering sounds during sleep biased AC activity patterns, and sound-biased AC patterns predicted subsequent hippocampal activity. These findings suggest that activation of specific cortical representations during sleep influences the identity of the memories that are consolidated into long-term stores.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

High-density, long-lasting, and multi-region electrophysiological recordings using polymer electrode arrays (2018, positive): “Generalized linear models during SWRs Construction of generalized linear models (GLMs) was done as reported previously (Rothschild et al., 2017).”
Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep. (2020, background): “In (Rothschild et al. 2017) it was shown that there is a bilateral dialogue between the auditory cortex (AC-CX) and CA1, where AC-CX pre-SWR firing predicted SWR content, which in turn predicted post-SWR AC-CX activity, thus suggesting a possible scenario in which ripples are first triggered by the ”
The Role of Hippocampal Replay in Memory and Planning (2018, neutral): “Subsequently, other authors have applied similar methods to identify coordination between the hippocampus and prefrontal cortex [94], auditory cortex [96], and grid cells in the deep layers (V and VI) of the medial entorhinal cortex [95] (Figure 4B) — the principal cortical projection target of the ”
How Memory Replay in Sleep Boosts Creative Problem-Solving (2018, background): “While replay is most commonly studied in the hippocampus, it has also been detected in other brain areas, such as the neocortex [68] and ventral tegmental area [69].”
Effects of Auxiliary Knowledge on Continual Learning (2022, background): “, a more effective modeling of previous real-world knowledge as it seems to happen in the human hippocampus [49].”