The pathogenesis of vasodilatory shock.

By D. Landry, J. A. Oliver. New England Journal of Medicine, 2001

1,044 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Early Lactate Clearance is Associated with Improved Outcome in Severe Sepsis and Septic Shock (2004, background): “Although the mechanisms are complex, global tissue hypoxia that accompanies severe sepsis and septic shock independently contributes to the systemic inflammatory response leading to endothelial activation (33, 34), vasodilation (35), release of inflammatory mediators (36), and modulation of the coag”
Tumor necrosis factor signaling (2003, background): “Indeed, the high systemic toxicity of TNF is caused by cellular mediators like NO and not related to its apoptosis-inducing capability.(189)”
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock* (2004, neutral): “Origin of infection, n (%) Community 262 (60) 201 (56) Hospital 135 (31) 112 (31) Intensive care unit 21 (5) 24 (7) Unknown 21 (5) 21 (6) Primary site of infection, n (%) Blood 17 (4) 12 (3) Gastrointestinal tract 50 (11) 34 (9) Intra-abdominal 100 (23) 96 (27) Respiratory tract 172 (39) 133 (37) Sk”