DNA repair mechanisms in dividing and non-dividing cells

By T. Iyama, David M. Wilson III. DNA Repair, 2013

684 citations recorded by the source corpus.

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple forms, and if allowed to persist, can promote genome instability and directly lead to various human diseases, particularly cancer, neurological abnormalities, immunodeficiency and premature aging. To avoid such deleterious outcomes, cells have evolved an array of DNA repair pathways, which carry out what is typically a multiple-step process to resolve specific DNA lesions and maintain genome integrity. To fully appreciate the biological contributions of the different DNA repair systems, one must keep in mind the cellular context within they operate. For example, the human body is composed of non-dividing and dividing cell types, including, in the brain, neurons and glial cells. We describe herein the molecular mechanisms of the different DNA repair pathways, and review their roles in non-dividing and dividing cells, with an eye towards how these pathways may regulate the development of neurological disease.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3507fee92ab86516016b0d2b677a7ddf740f3cb9

Citations in the corpus

• DNA damage and its links to neurodegeneration (2014, neutral): “Interestingly, the fraction of XP patients that develop neurological phenotypes correspond to those with mutations in genes such as XPA, XPB, XPD, XPF, and XPG that would cripple both GG-NER and TC-NER (Iyama and Wilson, 2013).”