Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

By M. Farrant, Z. Nusser. Nature Reviews Neuroscience, 2005

2,146 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/34e66a42c302bd36b3e87b6a06bc982a37aa1709

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Citations in the corpus

Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of γ‐aminobutyric acid type A receptor α1 subunit knockout mice (2006, neutral): “© 2006 WILEY-LISS, INC. hibition, respectively (Farrant and Nusser, 2005; Moss and Smart, 2001).”
Synaptic integration and plasticity of new neurons in the adult hippocampus (2008, background): “These neurotransmitters activate neurons not only locally within synaptic clefts (phasic activation), but also at a distance after diffusion out of synapses (tonic activation) (Farrant & Nusser, 2005; Ge et al. 2007a).”
Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo (2007, background): “In addition to the phasic activation of GABAA receptors during synaptic transmission, recent studies have revealed the presence of tonic GABA actions characterized by a slow time course and prolonged activation of GABAA channels (Farrant and Nusser, 2005).”
Pathway-Specific Drive of Cerebellar Golgi Cells Reveals Integrative Rules of Cortical Inhibition (2018, background): “temporal sharpening of thalamic input in neocortical pyramidal neurons (Pouille and Scanziani, 52 2001; Farrant and Nusser, 2005; D'Angelo and De Zeeuw, 2009; Nieus et al., 2014).”
Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus (2009, background): “There are several forms of GABAergic signaling in the brain (Farrant and Nusser, 2005).”
Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene (2006, background): “In contrast, tonic inhibition is thought to arise primarily from ambient GABA acting on extrasynaptic GABARs containing two 4 or 6 subunits with two subunits and a subunit (Mody, 2001; Farrant and Nusser, 2005).”
Mechanisms of Gamma Oscillations (2012, background): “Because the duration of IPSCs (inhibitory postsynaptic current) is determined by the subunit composition of the GABAA receptor (cf. Farrant & Nusser 2005), the frequency of gamma oscillations in the I-I model is determined mainly by the kinetics of the IPSPs and the net excitation of interneurons…”
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal (2008, positive): “So far, 19 receptor subunits have been cloned, but the vast majority (>85%) of neuronal GABA A receptors are composed of α 1 β 2 γ 2 (the most abundant subunit combination), α 2 β 3 γ 2 or α 3 β 1–3 γ 2 (Ref”
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “The physiological and pharmacological importance of perisynaptically and extrasynaptically localized GABA A -Rs has recently become increasingly appreciated (Mody and Pearce, 2004; Semyanov et al., 2004; Farrant and Nusser, 2005).”
Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “…openings make such a major contribution to the total charge that flows across the membrane (Belelli et al., 2005; Brickley et al., 1996; Nusser and Mody, 2002), it is not surprising that this type of conductance is capable of modulating both cell and network behavior (Farrant and Nusser, 2005).”