Uric acid and oxidative stress.

By G. Glantzounis, E. Tsimoyiannis, A. Kappas, D. Galaris. Current pharmaceutical design, 2005

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Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, background): “For a detailed discussion of nonenzymatic antioxidants, the reader is referred to numerous published reviews (97, 123, 177, 178, 184, 298, 303, 408).”
Uric acid and inflammatory markers. (2006, background): “This theory has a strong rationale in the biochemical characteristics of UA as anti-oxidant and is supported by pre-clinical studies performed in vitro and in experimental animals.(5) However, the role of UA in humans is still uncertain.”
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. (2007, methodology): “Finally, we measured levels of uric acid, a major antioxidant scavenger of hydroxyl radical and peroxynitrite [37], in serum samples from the subjects.”
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. (2007, background): “Since the discovery in 1981 that urate is a powerful chemical antioxidant, which is present in human plasma in concentrations much higher than ascorbate (2), it is widely accepted that high blood levels of uric acid in humans carry an evolutionary advantage and that uric acid is a major antioxidant ”