Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.

By S. Demaria, N. Kawashima, Anne Marie Yang, M. Devitt, J. Babb, James P. Allison, S. Formenti. Clinical Cancer Research, 2005

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An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer (2013, background): “The remarkable abscopal response seen in this patient after treatment with local radiotherapy and ipilimumab is consistent with data in preclinical models that this combination can induce therapeutically effective antitumor immune responses to poorly immunogenic carcinomas (5, 8, 16).”
Oncology meets immunology: the cancer-immunity cycle. (2013, background): “Although it is assumed that many might be antagonistic, there are some reports that others might promote T cell activity (Demaria et al., 2005; Duraiswamy et al., 2013; Hiniker et al., 2012; Ott et al., 2013; Postow et al., 2012; Stagg et al., 2011; Zitvogel et al., 2013).”
Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas (2013, unknown): “Previous studies have shown that fractionated RT synergizes with CTLA-4 blockade to produce tumor regression and long-term survival in a variety of extracranial cancer models (13, 14).”