Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.

By E. Rizos, E. Ntzani, E. Bika, M. Kostapanos, M. Elisaf. Journal of the American Medical Association (JAMA), 2012

1,039 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Surgery

View Paper: https://www.semanticscholar.org/paper/3432f158737f68c0f0f57747d8e19e7f30eeadc3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. D. Tocher
2. I. Graham
3. T. Ivanova
4. S. Grundy

In Surgery

1. D. Tocher
2. I. Graham
3. T. Ivanova
4. S. Grundy
5. Alberico L. Catapano

Citations in the corpus

• Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity – A Comprehensive Review (2016, neutral): “demonstrate risk reductions for cardiac death, but not total CVD, CHD, or stroke.(109) However, these latter pooled results”
• 2016 European Guidelines on cardiovascular disease prevention in clinical practice (2017, neutral): “prevention of recurrent CV events and mostly using fish oil supplements, showed no benefit of fish oil supplementation on CVoutcomes [315].”
• Omega-3 long-chain polyunsaturated fatty acids and aquaculture in perspective (2015, background): “Until recently, meta-analyses were also largely positive although there have been some recent studies showing less effect (Rizos et al., 2012; Chowdhury et al., 2014).”
• 2016 European Guidelines on cardiovascular disease prevention in clinical practice. (2016, methodology): “it is debatable whether they exert a favourable effect on all-cause, CAD, and stroke mortality.(314,315)”
• 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. (2016, methodology): “ical outcomes in two more recent trials using modern evidence-based prevention therapies (most patients were on statins), and therefore cannot be recommended in routine practice.(361) Furthermore, in pa-”
• National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2. (2015, methodology): “The Rizos et al.(144) meta-analysis has been criticized because the authors used a critical value for declaring statistical significance of 0.”
• Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. (2018, background): “Since Hooper 2004 was published, several other systematic reviews have suggested a lack of effect for omega-3 fats on all-cause mortality or a variety of CVDs (Campbell 2013; Chowdhury 2012; Khoueiry 2013; Kotwal 2012; Kwak 2012; Mariani 2013; Rizos 2012; Zheng 2014).”
• Reducing the Global Burden of Cardiovascular Disease, Part 1: The Epidemiology and Risk Factors. (2017, background): “Protection is attributed to omega-3 and omega-6 fatty acids, but RCTs of fish oil supplementation have shown no benefit.(75) Whether this is related to a truly neutral effect, or limited bioavailability of supplemental polyunsaturated fats (as compared with”