Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs
By K. Doan, J. Humphreys, Lindsey O. Webster, S. Wring, Larry J. Shampine, C. Serabjit-Singh, K. Adkison, J. Polli. Journal of Pharmacology and Experimental Therapeutics, 2002
617 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/33ebb37473bd3b98b58a5246f4626181be3d4648
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Citations in the corpus
- Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. (2004, background): “In addition, molecules of a given molecular weight, which contain rotatable bonds and those that are highly branched, have a reduced penetration of the BBB (Doan et al., 2002).”
- Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors (2017, methodology): “Therefore, surrogate models are frequently applied to identify compounds that may interact with P-gp and BCRP at the BBB (Mahar Doan et al., 2002; Wang et al., 2005; Feng et al., 2008; Hakkarainen et al., 2010; Hellinger et al., 2012; Chen et al., 2013; Hu et al., 2014), inclusively as screening…”
- Coexistence of passive and carrier-mediated processes in drug transport (2010, background): “At the same time, passive transcellular transport also has an important rol”