Myc deletion rescues Apc deficiency in the small intestine

By O. Sansom, V. Meniel, V. Muncan, T. Phesse, Julie A. Wilkins, K. Reed, K. Vass, D. Athineos, Hans Clevers, A. Clarke. Nature, 2007

633 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/33a992e7a74d356ad9f41133ca71bd5a4fb3f7b7

How researchers see this paper

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In Molecular Biology

1. George A. Calin
2. C. V. Dang
3. M. Ferracin
4. M. Negrini
5. M. Clarke
6. M. Shimizu
7. H. Ling
8. S. Sen

In Pathology and Forensic Medicine

1. Hans Clevers

Citations in the corpus

• Myc's broad reach. (2008, background): “Two studies have demonstrated that c-Myc is required for the formation of intestinal tumors that are initiated by conditional deletion of the APC gene (Sansom et al. 2007) and of skin tumors in the classic DMBA/ TPA driven model of Ras-dependent skin carcinogenesis (Oskarsson et al.”
• Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy (2008, background): “cMyc has recently been demonstrated to mediate nuclear bcatenin-mediated tumorigenesis in the APC-deficient mouse model of intestinal neoplasia [46].”
• MYC on the Path to Cancer (2012, background): “Although MYC is required for colonic epithelial turnover, deletion of MYC in mouse hepatocytes does not inhibit liver regeneration (Baena et al., 2005; Li et al., 2006; Sansom et al., 2007; Wilkins and Sansom, 2008).”
• MYC, metabolism, cell growth, and tumorigenesis. (2013, background): “Indeed, loss-of-func- tion analysis of MYC documents its central role in the growth programs of T lymphocytes, keratinocytes, and intestinal crypt cells (Zanet et al. 2005; Sansom et al. 2007; Wang et al. 2011).”
• The intestinal crypt, a prototype stem cell compartment. (2013, background): “, 2006), whereas adenoma formation by APC deletion in crypts was blocked by simultaneous cMyc deletion (Sansom et al., 2007).”
• CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer (2013, background): “In- versely, Myc deletion rescues APC deficiency in the mouse intestine (Sansom et al. 2007).”