Mutations in the APC tumour suppressor gene cause chromosomal instability

By R. Fodde, J. Kuipers, C. Rosenberg, R. Smits, M. Kielman, C. Gaspar, J. V. Es, C. Breukel, J. Wiegant, R. Giles and 1 more. Nature Cell Biology, 2001

772 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/3396b587e7b9b2410078a6dfa8d042691b65ee5b

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In Cell Biology

1. A. Cano
2. Hans Clevers

In Molecular Biology

1. A. Cano
2. Xianyang Yio
3. Hans Clevers
4. S. Itzkowitz
5. R. Nusse
6. M. Nieto
7. R. Weinberg
8. Elaine Fuchs

In Pathology and Forensic Medicine

1. Hans Clevers
2. J. Jass

Citations in the corpus

• APC, Signal transduction and genetic instability in colorectal cancer (2001, background): “cgi?Q=wnt%20not%20dkk*%20not%20fzd*%20not%20sfrp*%20not%20wrch-1%20not%20loc56998%20not%20ryk%20not%20wif-1%20not%20wisp*&ORG=Hs">WNT signal transduction pathway, to cell adhesion, migration and apoptosis, and chromosomal segregation at mitosi”
• Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. (2004, background): “gression (48), APC still contributes to the process of CIN (32).”
• Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling (2001, background): “In addition, APC mutations may also be responsible at least in part for chromosomal instability in colon cancer cells (Fodde et al., 2001; Kaplan et al., 2001).”
• Classification of colorectal cancer based on correlation of clinical, morphological and molecular features (2007, background): “In addition, particular environmental factors may be important in the pathogenesis of these CRCs.”